Phenylethylmalonic ester.



HEINRICH, HoBLEm,

FARBENFABRIKEN VORM. FRIEDR. BAYER & CO.,

CORPORATION 015 GERMANY.

OF VOHWINKEL, NEAR ELBERFELD, GERMANY, ASSIGNOR TO OF ELBERFELD,GERMANY, A

PHENYLETHYLMALONIC ESTER.

No Drawing.

Specification of Letters Patent. Application filed January 31, 1912.Serial No. 674,473.

Patented Aug. 27, 1912.

To all whom it may concern:

Be it known that I, HEINRICH HoRLEIN, doctor of philosophy, chemist,citizen of the German Empire, residing at Vohwinkel, near. Elberfeld,Germany, have invented new and useful Improvements in PhenylethylmalonicEsters, of which the following is a specification.

I have found that the hitherto unknown phenylethyl-malonic esters can beobtained by treating the phenylmalonie esters with ethylbromid. The newesters are valuable intermediate products for the production ofsubstituted barbituric acids which are valuable therapeutic compounds.Upon treatment with caustic alkali they are split'up into alcohols andphenylethylmalonic acid melting at 160 C.

The esters of'the present invention have the following general formula:

CzHs 00R (Rzalkyl, aralkyl, aryl).

In order to illustrate the new process more fully the following exampleis given, the parts being by weight :-236 parts of phenlymalonic esterand 120 parts of ethyl-bromid (BI-C 11 are added to a solution of 23parts of sodium in 230 parts of alcohol (free from water). The resultingmixture is then heated to boiling in a vessel provided with a refluxcondenser until the liquid shows a neutral reaction to lacmus. Theliquid is filtered, the alcohol is distilled off and the ester isisolated in the usual way. It is a limpid oil boiling at 166 C. under apressure of 12 min.

I claim 1. As new products, the phenylethylmalonic esters being liquidswhich are split up by the action of caustic alkali into alcohols and thephenylethylmalonic acid, substantially as descrlbed.

2. The phenylethylmalonic ethyl ester, being a limpid oil, boilin at 166C. under a pressure of 12 mm.,.an' being split up by the action ofcaustic alkali into alcohol and the phenylethylmalonic acid,substantially as described.

In testimony whereof I have hereunto setmy hand in the presence of twosubscribing witnesses.

HEINRICH HORLEIN. [L.s.]

Witnesses HELEN NUFER, A. Nurnn.

